Gabapentin and pregabalin are two widely used medications in the treatment of neuropathic pain, epilepsy, and various anxiety disorders. Both drugs belong to the class of anticonvulsants and share similar mechanisms of action, yet they have distinct pharmacological profiles, dosing regimens, and side effects. This article aims to explore the benefits and risks of gabapentin, particularly at doses like gabapentin 400mg, and pregabalin, including pregabalin 50mg, to provide a comprehensive understanding for patients and healthcare providers.